The LSPone HD delivers ultra-stable, pulseless flow at nanoliter-per-minute rates. With 13.5x higher microstepping (43,200 steps/mm), it ensures smooth motion and flow stability. It is ideal for sensitive microfluidic applications like organ‑on‑chip, droplet generation, and long-term perfusion. Same compact size and software interface as the standard LSPone model.
Includes the LSPone, power supply, software, glass syringe of your choice, USB cable, and syringe change tool. Fittings have be ordered separately.
General
The LSPone HD High-Precision Syringe Pump is a state-of-the-art dosing instrument engineered for ultra-low flow microfluidic applications. With enhanced microstepping technology, it delivers exceptionally smooth and nearly pulseless flow down to the nanoliter-per-minute range, comparable to a pressure controller. It is ideal for high-precision liquid handling tasks from milliliters to nanoliters.
Equipped with an integrated zero-dead-volume rotary valve, the LSPone HD allows efficient management of multiple fluids using a single syringe pump, maximizing cleaning efficiency and minimizing carryover. Its compact form factor and intuitive software interface ensure ease of use, making it the perfect solution for advanced laboratory workflows without requiring a large investment.
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Syringe volume
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Min. flow rate
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Max. flow rate
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Min. dosing volume
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50 μL
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7.17 nL/min
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500 μL/min
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0.1 μL
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100 μL
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14.4 nL/min
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1 mL/min
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0.2 μL
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250 μL
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35.9 nL/min
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2.5 mL/min
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0.5 μL
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500 μL
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71.7 nL/min
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5 mL/min
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1 μL
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1 000 μL
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143 nL/min
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10 mL/min
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2 μL
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Features
- Ultra‑low pulseless flow down to 7 nL/min thanks to HD microstepping
- Zero-dead-volume rotary valve with 6, 10 or 12 ports
- Chemical compatibility: PTFE, PCTFE, borosilicate glass, ideal for bio/chem fluids
- Programmable via simple GUI or scripting (Python, LabVIEW)
- Plug‑and‑play, USB powered, battery‑ready
Exceptional Flow Stability
Unlike traditional syringe and peristaltic pumps that often produce pulsatile or unstable flow at ultra-low rates, the LSPone HD achieves unprecedented stability thanks to its enhanced resolution.
With the LSPone HD, there's no need for flow dampers, pressure sensors, or closed-loop control. You get:
✅ Pulseless, stable flow across the entire range
✅ Direct volumetric control without pressure drift
✅ Reliable performance for sensitive applications like organ‑on‑chip, single-cell experiments, and gradient generation
Result: A cleaner baseline, better reproducibility, and greater control over your experimental conditions, especially at the nanoliter scale.
Applications
Sequential injection
The LSPone is ideal for automated sequential injections in multi-step chemical workflows. Its programmable functionality enables precise control over both timing and volume, making it well-suited for executing complex protocols with high reproducibility. Typical applications include surface functionalization, coating processes, and advanced techniques in spatial biology.
Volumetric injection
For applications demanding precise volumetric control, the LSPone ensures highly accurate liquid injections. This capability is especially valuable during sample preparation, where delivering exact reagent volumes is essential for consistency and performance. Common use cases include droplet microfluidics and microparticle synthesis (LNPs, EVs).
Dilution
The programmable control of the LSPone enables the automated preparation of complex mixtures and precise dilutions of samples or reagents. This streamlines workflows, enhances reproducibility, and significantly reduces the need for manual handling. Typical applications include gradient generation, buffer exchange, and sample preparation.
See the Documentation tab for Application Notes and Articles featuring the LSPone.
Special Offer
Get a special discount when purchasing 2 LSPone pumps together!
Content
1x LPSone body with distribution valve (PCTFE/PTFE, channel diameter 0.5 mm)
1x Glass syringe
1x Syringe change tool
1x Power supply with local power plug
1x USB cable
LSPoneQuick software is included.
Fittings are not included (see the Related Products).
Specifications
| Max Pressure |
7 bars (102 psi) |
| Wetted Materials |
PTFE or UHMW‑PE, PCTFE, borosilicate glass |
| Syringe Size |
50 µL – 1 mL |
| Dead Volume |
None (zero‑dead‑volume valve) |
| Plunger Travel & Steps |
30 mm - 1 296 000 micro‑steps |
| Plunger Drive |
Screw drive with linear encoder |
| Accuracy |
< 1 % deviation full stroke |
| Minimum Dosing Volume |
0.1 – 2 µL (depending on syringe) |
| Valve Ports & Channel Size |
6 / 10 / 12 ports; Ø 0.5 / 1.0 mm |
| Tube Fittings |
1/4‑28 UNF flat‑bottom |
| Interface |
USB‑mini, RS232/RS485 over USB |
| Power Consumption |
18–24 VDC, 2.2 A peak, 40 W |
| Stroke Time Range |
6 s – 6 400 min |
| Operating Temp. |
15 – 45 °C (59–113 °F) |
| Operating Humidity |
20 – 80 % non‑condensing |
| Dimensions (L×W×H) |
247×147×85 mm |
| Weight |
2.2 kg |
| Software/OS |
LSPoneQuick; Windows 10+ (also supports Python & LabVIEW) |
| Certifications |
CE & CB |
Note: Valve configurations and syringe sizes are selectable. Specifications may vary slightly depending on configuration and fluid type.
Valve specifications
| Valve configuration |
Zero dead-volume multi-port distribution with angular encoder |
| Number of ports |
6 |
10 |
12 |
| Channel diameter |
0.5 mm |
0.5 mm |
1.0 mm |
0.5 mm |
| Internal volume |
3.6 µL |
4.6 µL |
15 µL |
4.6 µL |
| Carryover volume |
2.6 µL |
2.8 µL |
8 µL |
2.8 µL |
| Tube port fittings |
Standard 1/4-28 UNF, flat-bottom |
| Dead volume |
None |
| Valve body material |
PTFE |
| Valve plug material |
PCTFE |
| Max. pressure |
7 bar (102 psi)
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Note: Valve configurations and syringe sizes are selectable. Specifications may vary slightly depending on configuration and fluid type.
Documentation
LSPone brochure
LSPone operating manual
LSPone quick start guide
LSPoneQuick software manual
Maintenance guide
STEP file available on request.
Published Research using the LSPone
✅ High-throughput Proteomics Automation
In Yucel et al., 2024 (Nature Communications Biology), they developed a fully automated pipeline for preparing samples in proteomics. The LSPone helped automate fluid exchanges and sample transfers, reducing manual labor and improving consistency.
➕ Buffer exchange, sample prep, multi-step automation
→ Read the article
✅ Droplet Microfluidics & Microparticle Synthesis
Wang et al., 2024 (Digital Discovery) utilized the LSPone to control droplet formation and reagent injection in a machine-learning-guided synthesis platform for polymer microparticles. The pump’s precise volume control was key to reproducible particle generation.
➕ Droplet microfluidics, microparticle synthesis, precise dosing
→ Read the article
✅ Sample Prep for Immune System Analysis
In Li et al., 2023 – Cell Reports Methods (PubMed), they describe a microfluidic system for preparing tiny biological samples to study how the immune system recognizes disease. The LSPone helped automate the cleaning and preparation steps needed before analysis.
➕ Sample preparation, automated workflows, low-volume handling
→ Read the article
