These idealized co-culture designs are helpful tools in the organ-on-chip field to mimic cellular interactions in vitro. This design is composed of a central chamber surrounded by two outer channels, allowing the modeling of a wide range of cell-cell interactions.
Description
The IMN2 Radial organ-on-chip design is made of a central chamber (tissue chamber) and two outer channels. This side-by-side architecture enables the co-culture of different cell types with real-time visualization. These platforms allow the modeling of physiological shear stress and in vivo-like morphology of tissues.
The separation between the central and outer channels can be done with either slits or pillars and are available in several dimensions. In both cases, slits/pillars are spaced at regular intervals to create a barrier between the inner and outer chambers.
These designs can be used in a wide range of applications: modeling of tumors (SynTumor), studies on inflammation processes (SynRAM), toxicology studies (SynTox), or modeling of the blood-brain barrier (SynBBB). For the latter one, a version including TEER measurement is also available to measure electrical resistance for non-invasive barrier assessment. You can refer to the specific product pages of those applications for more information and protocols.
Content
3x IMN2 Radial chip
Specifications
The chips have the format of a microscopic slide and are made of PDMS bonded to glass.
With slits:
| |
SY-102004 |
SY-102005 |
SY-102006 |
SY-102015 (TEER) |
SY-102016 |
SY-102017 |
| Outer channel (µm) |
100 |
200 |
200 |
200
|
200 |
200 |
| Barrier type |
Slits |
Slits |
Slits |
Slits |
Slits |
Slits |
| Slit/pillar spacing S (µm) |
100 |
50 |
50 |
50 |
50 |
50 |
| Slit width Ws (µm) |
2 |
3 |
3 |
3 |
2 |
2 |
| Pillar height (µm) |
- |
- |
- |
- |
- |
- |
| Travel T (µm) |
50 |
50 |
100 |
50 |
50 |
100 |
| Depth (µm) |
100 |
100 |
100 |
100 |
100 |
100 |
| Examples of applications |
SynTumor
|
SynBBB |
SynTumor |
SynBBB-TEER |
SynTox |
SynTox |
| Chips from starter/assay kits |
Yes |
Yes |
- |
Yes |
Yes |
- |
With pillars:
| |
SY-102007 |
SY-102008 |
SY-102009 |
SY-102010 |
SY-102011 |
SY-102012 |
| Outer channel (µm) |
200 |
200 |
200 |
200 |
200 |
200 |
| Barrier type |
Pillars |
Pillars |
Pillars |
Pillars |
Pillars |
Pillars |
| Slit/pillar spacing S (µm) |
3 |
8 |
3 |
8 |
3 |
8 |
| Slit width Ws (µm) |
- |
- |
- |
- |
- |
- |
| Pillar height (µm) |
3 |
3 |
3 |
3 |
8 |
8 |
| Travel T (µm) |
100 |
50 |
50 |
100 |
100 |
50 |
| Depth (µm) |
100 |
100 |
100 |
100 |
100 |
100 |
| Examples of applications |
SynRAM |
SynRAM |
SynRAM |
SynRAM |
SynRAM |
SynTumor |
| Chips from starter/assay kits |
- |
Yes |
- |
- |
- |
Yes |
