SynTox is a new 3D toxicology model, modeling a histological tissue slice under dynamic conditions. While other in vitro models fail to reproduce physiological features like morphological size or physiological blood flow, SynTox has proven its efficacy as an efficient model to reproduce in vivo conditions.
General
SynTox is the 3D toxicology model by excellence. This microfluidic chip allows real-time optical monitoring and a multi-compartment, multi-cellular architecture with low reagent requirements. This device offers many advantages:
- Physiologically realistic 3D morphological, fluid and cellular conditions
- Universal platform with specific architecture of the desired organ
- Significant reduction in the cost of consumables
- Robust and easy to use protocols
- Compatible with standard analytical instruments for on-chip and off-chip testing, including omics methodologies for systems biology and bioinformatics analysis
Starter Pack - To order the chip only, check our dedicated pages for linear and radial designs (ref SY-102016, SY-108013).
Applications
- Drug-induced vascular leakage
- Vascular inflammation
- Biomarker analysis
- Efficacy and toxicity screening
Examples of models developed using SynTox devices
Liver model with endothelial cells and hepatocytes. Acetaminophen toxicity on hepatocytes following bolus injection. Peripheral hepatocytes show severe toxicity.
Drug toxicity on cardiac cells. Left panel indicates viable cells while right panel indicates mixture of live and dead cells following drug treatment.
Content
12x SynTox chips (choice of IMN2 radial or IMN2 linear)
1x Pneumatic priming device (required for priming tubing to remove air)
1x Manifold (allows for multiple devices)
1x Tygon Tubing .02"ID X .06"OD (100 ft)
25x Slide Clamps
50x Blunt Tip Needles
50x 1mL Syringes with Luer-Lok® Tip
This kit does not include the air pump needed to establish the air-liquid interface.
Specifications
Documentation
?SynVivo brochure
?SynVivo starter kit brochure
?SynTox technical manual
